NICOTINAMIDE INCREASES INTRACELLULAR NAD+ CONTENT TO ENHANCE AUTOPHAGY-MEDIATED GROUP A STREPTOCOCCAL CLEARANCE IN ENDOTHELIAL CELLS

Nicotinamide Increases Intracellular NAD+ Content to Enhance Autophagy-Mediated Group A Streptococcal Clearance in Endothelial Cells

Group A streptococcus (GAS) is a versatile pathogen that causes a wide spectrum of diseases in humans.Invading host cells is a known strategy for GAS to avoid antibiotic killing and immune recognition.However, the underlying mechanisms of GAS resistance to intracellular killing need to be explored.Endothelial HMEC-1 cells were infected with GAS, me

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Comparative pangenome analysis of Enterococcus faecium and Enterococcus lactis provides new insights into the adaptive evolution by horizontal gene acquisitions

Abstract Background Enterococcus faecium and E.lactis are phylogenetically closely related lactic acid bacteria that are ubiquitous in nature and are known to be beneficial or pathogenic.Despite their considerable industrial and clinical importance, comprehensive studies on Whey Protein their evolutionary relationships and genomic, metabolic, and p

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